Research Progress Research Articles

Research progress in the treatment of inflammatory bowel disease with natural polysaccharides and related structure-activity relationships.

Inflammatory bowel disease (IBD) comprises a group of highly prevalent and chronic inflammatory intestinal tract diseases caused by multiple factors. Despite extensive research into the causes of the disease, IBD's pathogenic mechanisms remain unclear. Moreover, side effects of current IBD therapies restrict their long-term clinical use. In contrast, natural polysaccharides exert beneficial anti-IBD effects and offer advantages over current anti-IBD drugs, including enhanced safety and straightforward isolation from abundant and reliable sources, and thus may serve as components of functional foods and health products for use in IBD prevention and treatment. However, few reviews have explored natural polysaccharides with anti-IBD activities or the relationship between polysaccharide conformation and anti-IBD biological activity. Therefore, this review aims to summarize anti-IBD activities and potential clinical applications of polysaccharides isolated from plant, animal, microorganismal, and algal sources, while also exploring the relationship between polysaccharide conformation and anti-IBD bioactivity for the first time. Furthermore, potential mechanisms underlying polysaccharide anti-IBD effects are summarized, including intestinal microbiota modulation, intestinal inflammation alleviation, and intestinal barrier protection from IBD-induced damage. Ultimately, this review provides a theoretical foundation and valuable insights to guide the development of natural polysaccharide-containing functional foods and nutraceuticals for use as dietary IBD therapies.

MOFs-Based Materials with Confined Space: Opportunities and Challenges for Energy and Catalytic Conversion.

Metal-Organic Frameworks (MOFs) are a very promising material in the fields of energy and catalysis due to their rich active sites, tunable pore size, structural adaptability, and high specific surface area. The concepts of "carbon peak" and "carbon neutrality" have opened up huge development opportunities in the fields of energy storage, energy conversion, and catalysis, and have made significant progress and breakthroughs. In recent years, people have shown great interest in the development of MOFs materials and their applications in the above research fields. This review introduces the design strategies and latest progress of MOFs are included based on their structures such as core-shell, yolk-shell, multi-shelled, sandwich structures, unique crystal surface exposures, and MOF-derived nanomaterials in detail. This work comprehensively and systematically reviews the applications of MOF-based materials in energy and catalysis and reviews the research progress of MOF materials for atmospheric water harvesting, seawater uranium extraction, and triboelectric nanogenerators. Finally, this review looks forward to the challenges and opportunities of controlling the synthesis of MOFs through low-cost, improved conductivity, high-temperature heat resistance, and integration with machine learning. This review provides useful references for promoting the application of MOFs-based materials in the aforementioned fields.

Clinical research progress of callisperes® of drug-loaded microsphere arterial chemoembolisation in the treatment of solid tumors.

The incidence and mortality of cancer is ever-increasing, which poses a significant challengesto human health and a substantial economic burden to patients. At present, chemotherapy is still a primary treatment for various cancers. However, chemotherapy kills tumors but also induces the related side effects, whichadversely impacting patient quality of life and exacerbating suffering. Therefore, there is an urgent need for new and effective treatments that can control tumor growth while reducing the side effects for patients. Arterial chemoembolization has been attracted much attentionwhich attributed to the advantage of ability to embolize tumor vessels to block blood and nutrition supplies. Thus, to achieve local tumor control, it has become an effective means of local tumor control and has been widely used in clinical practice. Despite its efficacy, conventional arterial chemoembolization techniques, limited by embolization materials, have been associated with incomplete embolization and suboptimal drug delivery outcomes. Gradually, researchers have shifted their attention to a new type of embolic material called CalliSperes® drug-eluting embolic bead (DEB). DEB can not only load high doses of drugs, but also has strong sustained drug release ability and good biocompatibility. The integration of DEBs with traditional arterial chemoembolization (DEB-TACE) promises targeted vascular embolization, mitigated tumor ischemia and hypoxia, and direct intravascular chemotherapy delivery. It can prevent cancer cell differentiation and accelerate their death, meanwhile, directly injecting chemotherapy drugs into the target blood vessels reduced the blood concentration of the whole body, thus reduced the toxic and side effects of chemotherapy. Furthermore, DEB-TACE's sustained drug release capability elevates local drug concentrations at the tumor site, amplifying its antitumor efficacy. Therefore, DEB-TACE has become a hot spot in clinical research worldwide. This review introduces the pathogenesis of solid tumors, the background of research and biological characteristics of DEB, and the action mechanism of DEB-TACE, as well as its clinical research in various solid tumors and future prospects. This review aims to provide new ideas for the treatment of DEB-TACE in various solid tumors.

[Research progress in the diagnosis and treatment of childhood glaucoma].

Childhood glaucoma is a disease that seriously endangers children's visual health. It will accompany the patients throughout their lives and bring a heavy burden to families and society. Most childhood blindness caused by glaucoma is preventable or treatable. Relevant research has made progress in recent years. Based on the new consensus reached by the World Glaucoma Association and the latest medical evidence at home and abroad, this article summarizes the definition, classification, diagnosis, molecular genetics, pathogenesis and comprehensive treatments including drugs and surgery of childhood glaucoma, with a focus on the application of various surgical methods, so as to provide reference for clinical and scientific research and improve the clinical diagnosis and treatment of childhood glaucoma.

Targeting KRASG12D mutation in non-small cell lung cancer: molecular mechanisms and therapeutic potential.

Lung malignant tumors are a type of cancer with high incidence and mortality rates worldwide. Non-small cell lung cancer (NSCLC) accounts for over 80% of all lung malignant tumors, and most patients are diagnosed at advanced stages, leading to poor prognosis. Over the past decades, various oncogenic driver alterations associated with lung cancer have been identified, each of which can potentially serve as a therapeutic target. Rat sarcoma (RAS) genes are the most commonly mutated oncogenes in human cancers, with Kirsten rat sarcoma (KRAS) being the most common subtype. The role of KRAS oncogene in NSCLC is still not fully understood, and its impact on prognosis remains controversial. Despite the significant advancements in targeted therapy and immune checkpoint inhibitors (ICI) that have transformed the treatment landscape of advanced NSCLC in recent years, targeting KRAS (both directly and indirectly) remains challenging and is still under intensive research. In recent years, significant progress has been made in the development of targeted drugs targeting the NSCLC KRASG12C mutant subtype. However, research progress on target drugs for the more common KRASG12D subtype has been slow, and currently, no specific drugs have been approved for clinical use, and many questions remain to be answered, such as the mechanisms of resistance in this subtype of NSCLC, how to better utilize combination strategies with multiple treatment modalities, and whether KRASG12D inhibitors offer substantial efficacy in the treatment of advanced NSCLC patients.

Zinc‐Ion Battery Chemistries Enabled by Regulating Electrolyte Solvation Structure

AbstractDesigning next‐generation alternative energy storage devices that feature high safety, low cost, and long operation lifespan is of the utmost importance for future wide range of applications. Aqueous zinc‐ion batteries play a vital part in promoting the development of portability, sustainability, and diversification of rechargeable battery systems. Based on the theory of electrolyte solvation chemistry, deep understanding of interaction between electrolyte components and their impact on the chemical properties has achieved a series of research progress. Analyzing the solvation shell of electrolyte or structure–performance relationship, and establishing more stable and high‐energy battery chemistries are inevitable requirements to suppress the electrolyte–electrode interphase side reaction and realize the functional use of zinc‐ion batteries. In this critical review, the attempt is to overview the current comprehension regarding the electrolyte solvation structure in zinc battery technology. Advanced methodology toward the interactions between zinc cations, solvent molecules, and anions in zinc aqueous electrolytes and the general rules for electrolyte design from the atomic level are summarized. Methods for viable solvation modification are then introduced regarding overcoming the remained challenges for transferring the laboratory results to next‐generation practical applications. Possible research direction with the aim of investigating the ultimate choice for future high‐performance electrolyte solvation construction is also outlined.

[Clinical characteristics and research progress of ocular Merkel cell carcinoma].

Merkel cell carcinoma (MCC) is a rare, aggressive epithelial and neuroendocrine tumor. MCC typically presents as painless nodules or patches rapidly growing in sun-exposed skin areas. Ocular MCC accounts for approximately 2.5% of all cases and may be misdiagnosed as granuloma or basal cell carcinoma. Risk factors for development include advanced age, ultraviolet exposure, male gender, immunosuppression, and Merkel cell polyomavirus infection. Treatment involves wide local excision with adjuvant radiotherapy, chemotherapy is typically reserved for metastatic disease, and immunotherapy and targeted therapy are currently under investigation showing promising early outcomes. This article summarizes the clinical characteristics and research progress of ocular MCC.

Research progress on the detection of foodborne pathogens based on aptamer recognition.

Foodborne diseases caused by bacterial contamination are a serious threat to food safety and human health. The classical plate culture method has the problems of long detection cycle, low sensitivity and specificity, and complicated operation, which cannot meet the growing demand for rapid quantitative detection of pathogenic bacteria. The frequent outbreak of foodborne diseases has put forward higher requirements for rapid and simple detection technology of foodborne pathogens. Aptamer is a kind of oligonucleotide fragment that can recognize targets with the advantages of high affinity and good specificity. The target can be range from proteins, small molecules, cells bacteria, and even viruses. Herein, the latest advances in sensitive and rapid detection of foodborne pathogens based on aptamer recognition was reviewed. Special attention has been paid to the obtained sequences of aptamers to various foodborne pathogens, the optimization of sequences, and the mechanism of aptamer recognition. Then, the research progress of biosensors for the detection of pathogenic bacteria based on aptamer recognition were summarized. Some challenges and prospects for the detection of foodborne pathogens based on aptamer recognition were prospected. In summary, with the further deepening of aptamer research and improvement of detection technology, aptamer-based recognition can meet the needs of rapid, sensitive, and accurate detection in practical applications.

Transformer-based intelligent fault diagnosis methods of mechanical equipment: A survey

Abstract Transformer is extensively employed in natural language processing, and computer vision (CV), with the self-attention structure. Due to its outstanding long-range dependency modeling and parallel computing capability, some leading researchers have recently attempted to apply Transformer to intelligent fault diagnosis tasks for mechanical equipment, and have achieved remarkable results. Physical phenomena such as changes in vibration, sound, and heat play a crucial role in the research of mechanical equipment fault diagnosis, which directly reflects the operational status and potential faults of mechanical equipment. Currently, intelligent fault diagnosis of mechanical equipment based on monitoring signals such as vibration, sound, and temperature using Transformer-based models remains a popular research topic. While some review literature has explored the related principles and application scenarios of Transformer, there is still a lack of research on its application in intelligent fault diagnosis tasks for mechanical equipment. Therefore, this work begins by examining the current research status of fault diagnosis methods for mechanical equipment. This study first provides a brief overview of the development history of Transformer, outlines its basic structure and principles, and analyzes the characteristics and advantages of its model structure. Next it focuses on three model variants of Transformer that have generated a significant impact in the field of CV. Following that, the research progress and current challenges of Transformer-based intelligent fault diagnosis methods for mechanical equipment are discussed. Finally, the future development direction of Transformer in the field of mechanical equipment fault diagnosis is proposed.

Emerging contaminants in water environments: progress, evolution, and prospects

ABSTRACT This article employs bibliometric tools like VOSviewer, Bibliometrix, and CiteSpace for a comprehensive visual analysis of 1,612 documents on Emerging Contaminants in Waters from the Web of Science database. The objective is to elucidate the historical development, research hotspots, and trends in international studies of this field, offering valuable insights and guidance for future research directions. The analysis reveals a consistent increase in publications from 2003 to 2023, with the United States, China, and Spain being the most prolific contributors. A detailed examination of keyword co-occurrence and cluster analysis shows a predominant focus on themes such as pollutant detection, risk assessment, and biogeochemical cycling. Furthermore, the study underscores the significance of forming interdisciplinary networks among authors and institutions, highlighting its critical role in enhancing the quality and innovation of scientific research. The findings of this study not only chart the progression and focal points of research in this domain but also underscore the pivotal role of international collaboration, serving as an indispensable reference for shaping future research trajectories and fostering global cooperation.

Trend of pharmaceuticals 3D printing in the Middle East and North Africa (MENA) region: An overview, regulatory perspective and future outlook

The traditional method of producing medicine using the “one-size fits all” model is becoming a major issue for pharmaceutical manufacturers due to its inability to produce customizable medicines for individuals’ needs. Three-dimensional (3D) printing is a new disruptive technology that offers many benefits to the pharmaceutical industry by revolutionizing the way pharmaceuticals are developed and manufactured. 3D printing technology enables the on-demand production of personalized medicine with tailored dosage, shape and release characteristics. Despite the lack of clear regulatory guidance, there is substantial interest in adopting 3D printing technology in the large-scale manufacturing of medicine. This review aims to evaluate the research efforts of 3D printing technology in the Middle East and North Africa (MENA) region, with a particular emphasis on pharmaceutical research and development. Our analysis indicates an upsurge in the overall research activity of 3D printing technology but there is limited progress in pharmaceuticals research and development. While the MENA region still lags, there is evidence of the regional interest in expanding the 3D printing technology applications in different sectors including pharmaceuticals. 3D printing holds great promise for pharmaceutical development within the MENA region and its advancement will require a strong collaboration between academic researchers and industry partners in parallel with drafting detailed guidelines from regulatory authorities.

Thickness-Driven Synthesis and Applications of Covalent Organic Framework Nanosheets.

Covalent organic frameworks (COFs) are two-dimensional, crystalline porous framework materials with numerous scopes of tunability like porosity, functionality, stability and aspect ratio (thickness to length ratio). The manipulation of π-stacking in COFs results in truly 2D materials, namely covalent organic nanosheets (CONs) adds advantages in many applications. In this review, we have discussed both top-down (COFs→CONs) and bottom-up (molecules→CONs) with precise information on thickness and lateral growth. We have showcased the research progress of CONs in few selected applications like batteries, catalysis, sensing and biomedical applications. This review specifically highlights the reports where the authors compare the performance of CONs with COFs by demonstrating the impact of thickness and lateral growth of the nanosheets. Eventually, we have provided the possible scope of exploration of CONs research in terms of inter-dimensional conversion like graphene to carbon nanotube and future technologies..

Thickness‐Driven Synthesis and Applications of Covalent Organic Framework Nanosheets

Covalent organic frameworks (COFs) are two‐dimensional, crystalline porous framework materials with numerous scopes of tunability like porosity, functionality, stability and aspect ratio (thickness to length ratio). The manipulation of π‐stacking in COFs results in truly 2D materials, namely covalent organic nanosheets (CONs) adds advantages in many applications. In this review, we have discussed both top‐down (COFs→CONs) and bottom‐up (molecules→CONs) with precise information on thickness and lateral growth. We have showcased the research progress of CONs in few selected applications like batteries, catalysis, sensing and biomedical applications. This review specifically highlights the reports where the authors compare the performance of CONs with COFs by demonstrating the impact of thickness and lateral growth of the nanosheets. Eventually, we have provided the possible scope of exploration of CONs research in terms of inter‐dimensional conversion like graphene to carbon nanotube and future technologies..

Research on J wave detection based on transfer learning and VGG16

The J wave in the electrocardiogram indicates that the patient may suffer from malignant arrhythmia, ventricular tachycardia and other diseases, and the probability of sudden death is greatly increased. Due to the low incidence of J wave syndrome, J wave data in public databases are scarce, which hinders the research progress of J wave detection. Therefore, this study aims to automatically identify J wave signals, construct relevant datasets, and combine transfer learning with the pre-trained VGG16 model to detect J wave signals. Given the limited availability of J wave data, we utilized a local transformation method to simulate the generation of J wave signals. Subsequently, the simulated J wave signals underwent a continuous wavelet transform, converting them into grayscale images suitable for input into the pre-trained network. Finally, we fine-tuned the VGG16 network structure, which was initially trained on ImageNet, and modified the network for binary classification output for J wave data training. According to experimental results, this method achieves a 99.34 % accuracy rate, 99.35 % sensitivity, and 99.32 % specificity for the identification of J wave data. The aforementioned results outperform existing J wave research methodologies, effectively facilitating the identification of J wave signals.

Biological removal of nitrogenous waste compounds in the biofloc aquaculture system: a review

Abstract Aquaculture has experienced significant global expansion and is considered one of the fastest-growing sectors in food production. However, there exist additional challenges that restrict the capacity to achieve maximum efficiency in aquaculture systems, such as issues over water quality and shortages of appropriate live feeds. Intensive aquaculture systems involve the use of protein-rich prepared feed for feeding the cultured animals. This may give rise to the discharge of nitrogenous compounds into the water, which can pose a risk to the environment when present in excessive quantities beyond the acceptable levels. In recent years, an innovative method called biofloc technology (BFT) has become a practical solution to this issue. Undoubtedly, BFT offers a groundbreaking method for nutrient disposal that eradicates the requirement for excessive water use or equipment maintenance. Three primary types of microorganisms are crucial in alleviating the adverse impacts of nitrogen compounds in this technique. Photoautotrophs participate in the processes of removal and absorption, whereas chemoautotrophs promote nitrification and conversion. Heterotrophs contribute to the absorption process. Biofloc predominantly consists of heterotrophic bacteria, alongside algae, protozoa, rotifers, and nematodes. While there have been reviews carried out on multiple aspects of biofloc technology, there exists a lack of literature that tackles this particular field of research progress. This article discusses every aspect and techniques of biological management used for removing nitrogenous waste compounds in biofloc aquaculture systems.

Porous Organic Framework Materials (MOF, COF, and HOF) as the Multifunctional Separator for Rechargeable Lithium Metal Batteries.

The separator is an important component in batteries, with the primary function of separating the positive and negative electrodes and allowing the free passage of ions. Porous organic framework materials have a stable connection structure, large specific surface area, and ordered pores, which are natural places to store electrolytes. And these materials with specific functions can be designed according to the needs of researchers. The performance of porous organic framework-based separators used in rechargeable lithium metal batteries is much better than that of polyethylene/propylene separators. In this paper, thethree most classic organic framework materials (MOF, COF, and HOF) are analyzed and summarized. The applications of MOF, COF, and HOF separators in lithium-sulfur batteries, lithium metal anode, and solid electrolytes are reviewed. Meanwhile, the research progress of these three materials in different fields is discussed based on time. Finally, in the conclusion, the problems encountered by MOF, COF, and HOF in different fields as well as their future research priorities are presented. This review will provide theoretical guidance for the design of porous framework materials with specific functions and further stimulate researchers to conduct research on porous framework materials.

Crosstalk between brassinosteroids and other phytohormones during plant development and stress adaption.

Brassinosteroids (BRs) are a group of polyhydroxylated phytosterols that play essential roles in regulating plant growth and development as well as stress adaptation. It is worth noting that BRs do not function alone, but rather they crosstalk with other endogenous signaling molecules, including the phytohormones auxin, cytokinins (CKs), gibberellins (GAs), abscisic acid (ABA), ethylene (ET), jasmonates (JAs), salicylic acid (SA), and strigolactones (SLs), forming elaborate signaling networks to modulate plant growth and development. BRs interact with other phytohormones mainly by regulating each others' homeostasis, transport, or signaling pathway at the transcriptional and posttranslational levels. In this review, we focus our attention on current research progress in BR signal transduction and the crosstalk between BRs and other phytohormones.

Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells

The reprogramming of somatic cells to pluripotent stem cells has immense potential for use in regenerating or redeveloping tissues for transplantation, and the future application of this method is one of the most important research topics in regenerative medicine. These cells are generated from normal cells, adult stem cells, or neoplastic cancer cells. They express embryonic stem cell markers, such as OCT4, SOX2, and NANOG, and can differentiate into all tissue types in adults, both in vitro and in vivo. However, tumorigenicity, immunogenicity, and heterogeneity of cell populations may hamper the use of this method in medical therapeutics. The risk of cancer formation is dependent on mutations of these stemness genes during the transformation of pluripotent stem cells to cancer cells and on the alteration of the microenvironments of stem cell niches at genetic and epigenetic levels. Recent reports have shown that the generation of induced pluripotent stem cells (iPSCs) derived from human fibroblasts could be induced using chemicals, which is a safe, easy, and clinical-grade manufacturing strategy for modifying the cell fate of human cells required for regeneration therapies. This strategy is one of the future routes for the clinical application of reprogramming therapy. Therefore, this review highlights the recent progress in research focused on decreasing the tumorigenic risk of iPSCs or iPSC-derived organoids and increasing the safety of iPSC cell preparation and their application for therapeutic benefits.

Research progress in regional odontodysplasia

Regional odontodysplasia (ROD) is a rare localized dental developmental anomaly. The typical clinical manifestations of ROD are abnormal tooth eruption, abnormal development of enamel and dentin. The radiographic characteristic is "ghost teeth". Its etiology still remains unknown. The care and treatment of a patient with ROD needs a multidisciplinary approach. And the treatment should be taken after the assessment of each individual case of ROD. This paper reviews the definition, etiology, epidemiological features, clinical manifestations, imaging features, dental microstructure and treatment strategies of ROD to provide reference for clinical diagnosis and treatment.

Research progress in methylation modification in tooth root development

Methylation modification is one of the most common epigenetic modification regulation in eukaryotes, including histone methylation, DNA methylation, RNA methylation, etc., which plays an important regulatory role in physiological processes and pathologic occurrence and development. Tooth root development is carried out by both epithelial and mesenchymal cells and involves a variety of cell-molecular interactions. In recent years, a large number of studies have found that methylation plays a key role in the regulation of tooth root development and expands the mechanism network of tooth root development. In this paper, we review the role and mechanism of methylation modification during root development.